Chromosomal instability and genomic alterations in cholangiocarcinoma from Northeastern Thailand.

ABSTRACT: Cholangiocarcinoma (CCA) is a lethal cancer of the bile duct and is a major health concern in several parts of the world, including northeastern Thailand, where CCA incidence is the highest due to the endemic liver fluke Opisthorchis viverrini. Multiple studies have characterised genomic alterations in CCA tumours, and specific chromosomal alterations can predict prognosis. However, it is not known whether chromosomal instability (CIN), ongoing genomic alteration characteristic of most cancer types, is present in CCA tumours. In this study we leveraged a panel of cancer cell lines derived from fluke-positive CCA patients, as well as a matched normal cholangiocyte line as a control, to characterise CIN in CCA. We observed elevated rates of chromosome segregation errors compared to normal ce

SUBMITTER: Deenonpoe R 

PROVIDER: S-EPMC12531121 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature