Network-based mapping and neurotransmitter architecture of brain gray matter correlates of extraversion.

ABSTRACT:

Objective

To identify common functional brain networks underlying heterogeneous gray matter (GM) correlates of extraversion and to characterize the neurotransmitter receptor and transporter architecture associated with these networks.

Methods

A systematic literature search identified 13 voxel-based morphometry (VBM) studies reporting GM correlates of extraversion in healthy individuals (N = 1,478). Functional connectivity network mapping (FCNM) approach using normative resting-state functional MRI data from the Human Connectome Project (HCP, N = 1,093) mapped divergent GM correlates extraversion onto common networks. Robustness was assessed via replication using an independent Southwest University Adult Lifespan Dataset (SALD, N = 329) and sensitivity an

SUBMITTER: Sun HH 

PROVIDER: S-EPMC12531143 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature