Human umbilical cord mesenchymal stem cells recover chemotherapy-induced premature ovarian failure.

ABSTRACT:

Background

Current therapeutic approaches for premature ovarian failure (POF) are often inadequate in clinical practice and some raise ethical concerns. Human umbilical cord mesenchymal stem cells (hUC-MSCs) have emerged as a preferred option for cell transplantation, attributed to their facile extraction process and minimal immunogenicity.

Objective and methods

This study aimed to elucidate the transcriptomic alterations associated with hUC-MSCs treated in the context of POF mice and to explore their underlying biological mechanisms. POF mice were established via injecting cyclophosphamide (CTX) plus busulfan (BU). Subsequently, ovaries and serum were collected after 1 week for model identification. 4 weeks after hUC-MSCs transplantation, ovaries and serum were collected fo

SUBMITTER: Ji G 

PROVIDER: S-EPMC12531164 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature