Annexin A1 levels affect microbiota in health and DSS-induced colitis/inflammatory bowel disease development.

ABSTRACT:

Background

Inflammatory Bowel Diseases (IBDs) are characterized by intestinal dysbiosis and immune dysregulation. Annexin A1 (AnxA1) promotes epithelial repair and inhibits immune responses during IBD. However, AnxA1's impact on gut microbiota during IBD remains unclear. Here, we experimentally investigated the microbiota profile during colitis in wild-type (WT) and AnxA1-deficient mice (AnxA1^-/-), and evaluated an observational cohort in IBD patients with high or low AnxA1 expression.

Methods

Colitis was induced in C57BL/6 WT and AnxA1 ^-/- mice via oral administration of 2% DSS for six days. Fecal samples were collected at baseline, peak inflammation (day 6), and during the recovery phase (day 10) for 16S rRNA sequencing. Human mi

SUBMITTER: Filippi Xavier L 

PROVIDER: S-EPMC12531217 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature