Comparative outcomes of ureteroscopy and percutaneous nephrolithotomy in CKD patients with renal calculi: a propensity-matched cohort study.

ABSTRACT:

Background

Kidney stones frequently coexist with chronic kidney disease (CKD), sharing common risk factors and leading to adverse outcomes. While percutaneous nephrolithotomy (PCNL) and ureteroscopy (URS) are both effective treatment options, the safety of PCNL has been well-established in CKD patients, whereas the safety profile of URS remains less clear.

Methods

A retrospective cohort study using the TriNetX database was conducted to compare outcomes in CKD patients undergoing URS or PCNL. Patients aged ≥18 years with a diagnosis of renal stones and CKD were included, excluding those on dialysis. Propensity score matching (PSM) was performed to balance baseline characteristics. The primary outcome was the 5-year rate of major adverse kidney events (MAKE), a composite of mo

SUBMITTER: Chiou JK 

PROVIDER: S-EPMC12531238 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature