Inflammation induced by the new lineage of <i>Vibrio cholerae</i> serogroup O1 in the neonatal mouse model.

ABSTRACT:

Background

A novel lineage of serogroup O1 El Tor V. cholerae, genetically distinct from the seventh pandemic strain, has recently been identified in China and linked to diarrheal outbreaks. Investigations were conducted to examine the inflammation in the intestines of mice infected with V. cholerae strains including the new lineage strains VC6050 (ctxAB +) and VC6055 (ctxAB -), as well as the seventh pandemic strains of V. cholerae N16961.

Results

The result showed that the colonization abilities of V. cholerae in the intestines of mice infected with VC6050 and N16961 was significantly higher than that of the VC6055 group. Histological sections of the small intestine revealed a few inflammatory cell infiltrations in the muscularismu

SUBMITTER: Fu X 

PROVIDER: S-EPMC12531251 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature