Stage-specific fecal and salivary microbiota signatures for noninvasive detection of colorectal cancer.

ABSTRACT:

Background

Fecal and salivary microbiota dysbiosis play a crucial role in the pathogenesis of colorectal cancer (CRC). We investigated whether the fecal and salivary microbiota were altered during colorectal tumorigenesis and evaluated their diagnostic performance.

Methods

We enrolled 30 metastatic CRC patients, 30 nonmetastatic CRC patients, and 30 healthy controls between October 2023 and September 2024. Fecal and salivary samples were collected for microbial profiling via 16S rDNA sequencing and bioinformatics analysis.

Results

Fecal and salivary microbiota composition differed during CRC progression, with salivary microbiota progressively enriched in the gut. In addition, fecal and salivary microbial co-occurrence networks dynamically altered during CRC progressio

SUBMITTER: Wu Z 

PROVIDER: S-EPMC12531261 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature