Comprehensive Motility Analysis in Patients with Hypermobility Spectrum Disorders and Gastrointestinal Symptoms: An Exploratory Tertiary Care Study.

ABSTRACT:

Purpose

Disorders of gut-brain interaction (DGBI) affect up to 40% of people worldwide and in several studies an association with hypermobility spectrum disorders (HSD) was described. HSD patients frequently report gastrointestinal (GI) symptoms and GI dysmotility has been suggested as underlying mechanism. This study evaluates whether individuals with (undiagnosed) joint hypermobility and/or HSD show different GI symptom and motility patterns compared to those without hypermobility/HSD.

Methods

In this prospective open-label study, patients who were referred for GI motility assessment between 2016 and 2018 were included. Motility assessments included esophageal manometry, gastric emptying test, antro-duodenal manometry, colonic manometry, and/or a colonic transit study. Joi

SUBMITTER: Sweerts KWE 

PROVIDER: S-EPMC12531306 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature