Diagnostic Performance of Endoscopic Ultrasound-Guided Fine Needle Biopsy with Histological Analysis Versus Combined Cytohistological Analysis in Solid Pancreatic Lesions: A Systematic Review and Meta-Analysis.

ABSTRACT:

Background

Recent advancements in endoscopic ultrasound-guided fine needle biopsy (EUS-FNB) needles enable reliable histological evaluation, raising questions about the necessity of routinely adding cytological analysis.

Aim

To compare the diagnostic performance of EUS-FNB using histology alone versus combined cytohistological analysis for detecting solid pancreatic malignancies.

Methods

A comprehensive search of MEDLINE, Embase, and Cochrane databases identified studies reporting diagnostic performance, tissue adequacy, processing methods, and reference standards of surgical specimens, clinical, and imaging assessment. Pooled sensitivity, specificity, tissue adequacy, and heterogeneity were analyzed using meta-analytic techniques.

Results

Twenty-nine studies w

SUBMITTER: Termsinsuk P 

PROVIDER: S-EPMC12531314 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature