Intratumoral Microbe Correlated with Expression of DNA Methylation Genes in Hepatocellular Carcinoma.

ABSTRACT:

Background

Intratumor microbiota are increasingly implicated in cancer pathogenesis, with emerging evidence suggesting their role in regulating DNA methylation pathways in hepatocellular carcinoma (HCC). This study investigates the interactions between specific bacterial genera and key DNA methylation-related genes in HCC tissues.

Methods

Tumor and adjacent normal tissues from 72 HCC surgical patients were analyzed. Bacterial composition was characterized via 16SrRNA sequencing, while quantitative analysis assessed the abundance of differential bacterial genera and expression of DNA methylation pathway genes linked to HCC outcomes.

Results

Six bacterial genera exhibited differential abundance between tumor and normal tissues: Propionibacterium, Mycoplasma, Variovorax,

SUBMITTER: Chen W 

PROVIDER: S-EPMC12531316 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature