Oral Microbiota Linking Humoral Response, Periodontitis and Atherosclerosis.

ABSTRACT:

Aim

The humoral immune system is implicated in the link between periodontitis and atherosclerosis. This study aims to explore how interactions between the oral microbiota and humoral immune responses may contribute to this association.

Materials and methods

We analysed data from the Northern Finland Birth Cohort 1966, which included 1560 participants who underwent comprehensive health and oral examinations. Serum antibodies against phosphorylcholine (PCho) and malondialdehyde acetaldehyde (MAA) adducts were measured using chemiluminescence immunoassays. In a sub-cohort (n = 868), the oral microbiome from saliva samples was characterised using 16S rRNA gene sequencing.

Results

Higher serum levels of IgA and IgG to PCho, as well as IgA to MAA, were associated with an in

SUBMITTER: Akhi R 

PROVIDER: S-EPMC12531363 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature