Temporal Parameters Determine the Efficacy of Vagus Nerve Stimulation Directed Neural Plasticity.

ABSTRACT:

Background

Combining vagus nerve stimulation (VNS) with rehabilitation represents an emerging treatment for a range of neurological disorders, and identifying stimulation parameters that maximize the effects of VNS may provide a means to optimize this therapy. Prior studies show that varying the intensity of stimulation, which influences activity of the locus coeruleus and nucleus basalis in response to VNS, determines the strength of VNS-dependent enhancement of synaptic plasticity in cortical circuits. Objective: The impact of the temporal parameters of stimulation, such as frequency and distribution of pulses within a stimulation train, remains underexplored. In this study, we evaluated how varying these temporal parameters impacts the magnitude of VNS-directed plasticity

SUBMITTER: Addo JJA 

PROVIDER: S-EPMC12531385 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature