Orally Administered Edible Snail Extract Powder Enhances Skin Hydration via Hyaluronic Acid Synthesis and Barrier Gene Modulation in SKH-1 Hairless Mice.

ABSTRACT: SKH-1 hairless mice were used as the in vivo model in this study to evaluate the efficacy of oral snail extract powder (SEP) on skin hydration and barrier enhancement. The skin serves as a primary barrier against external stimuli and plays a critical role in maintaining water homeostasis. Optimal skin hydration is essential for preserving barrier integrity and preventing dermatological conditions such as xerosis and atopic dermatitis. Although edible snail has demonstrated moisturizing effects when applied topically, its efficacy following oral administration has not been sufficiently characterized. In this study, we evaluated the moisturizing efficacy and safety of orally administered edible snail extract powder in SKH-1 hairless mice. Animals were divided into a control group and three t

SUBMITTER: Lee C 

PROVIDER: S-EPMC12531416 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature