Insights Into CEST Contrast at 2 ppm in Enhancing and Nonenhancing Lesions From Glioma Patients Scanned at 7 T.

ABSTRACT:

Introduction

Chemical exchange saturation transfer (CEST) has been demonstrated to provide a noninvasive opportunity to image gliomas. Preclinical ultrahigh-field MRI studies have shown the value of the 2 ppm pool; however, in vivo studies in glioma patients are currently lacking. This study aimed to explore the 7 T MRI CEST contrast of the 2 ppm in gliomas and the tumor's different components.

Methods

Twenty-one glioma patients treated at two tertiary referral centers for brain tumors in the Netherlands were scanned. Regions of interest were defined as contrast-enhancing (CE-lesion), nonenhancing (NE-lesion) tumor, and the contralateral normal-appearing white matter (CL NAWM). Magnetization transfer ratio asymmetry (MTRasym), Lorentzian difference (LD), spillover and magnet

SUBMITTER: Schmitz-Abecassis B 

PROVIDER: S-EPMC12531428 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature