Kuanxiong aerosol attenuates post-myocardial infarction heart failure by immune modulation via the NOTCH1 pathway.

ABSTRACT:

Objective

To investigate the mechanisms underlying the therapeutic effects of Kuanxiong aerosol (KXA) in heart failure after myocardial infarction (HFAMI).

Methods

A HFAMI rat model was established. Echocardiography, H&E and TUNEL staining of heart tissue, and ELISA for HFAMI-related biomarkers were performed after KXA treatment. qPCR, Western blot, and flow cytometry were used to identify potential KXA targets in vivo and in vitro. Cell viability and apoptosis were evaluated using the Cell Counting Kit-8.

Results

KXA significantly decreased left ventricular end diastolic diameter (LVIDD, 6.49±0.40 mm, P<0.001) and left ventricular end-systolic dimension (LVISD, 3.72±0.27 mm, P<0.001), while increasing left ventricular ejection fraction (LVEF, 64.66±2.69%, P<0.001) an

SUBMITTER: Sun Z 

PROVIDER: S-EPMC12531556 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature