Causal effects of sleep behaviors on temporomandibular disorders and pain: a bidirectional mendelian randomization study.

ABSTRACT:

Background

Temporomandibular disorder (TMD) is a prevalent condition associated with pain and dysfunction of the temporomandibular joint (TMJ) and surrounding structures. Sleep disturbances are common in TMD patients, yet the bidirectional causal relationship between specific sleep behaviors and TMD remains unclear. This study aimed to investigate this relationship using a two-sample Mendelian randomization (MR) approach.

Methods

A bidirectional two-sample MR analysis was conducted using genome-wide association study (GWAS) summary statistics for seven sleep behaviors and TMD/TMD related pain (TMD-pain). Single nucleotide polymorphisms (SNPs) were used as instrumental variables. The analysis included data from the UK Biobank and FinnGen Consortium, focusing on individuals of

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC12531579 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature