Combined CA19-9, CA125, and CEA to predict prognosis of patients with intrahepatic cholangiocarcinoma after radical surgery: a retrospective, multi-institutional study.

ABSTRACT:

Purpose

In intrahepatic cholangiocarcinoma (ICC), the interactions among CA19-9, CA125, and CEA are not yet fully understood. This study aims to investigate the relationship between a combined grading system of CA19-9, CA125, and CEA (3C grade) and the prognosis of ICC patients, as well as its predictive capability for prognosis.

Methods

The patients were categorized into different 3C grades based on preoperative serum levels of CA19-9, CA125, and CEA to explore the relationship between 3C grade and overall survival (OS) and recurrence-free survival (RFS), assessing the predictive value of 3C grade for OS and RFS.

Results

A total of 535 eligible patients were included and were classified into different 3C grade groups. Significant differences were observed among diffe

SUBMITTER: Wang T 

PROVIDER: S-EPMC12531636 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature