Efficacy and Safety of Tirzepatide on Weight Loss in Patients Without Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

ABSTRACT: Tirzepatide has positive effects on weight loss in individuals with overweight or obesity. Considering its broad side-effect profile, its efficacy and safety in individuals without diabetes mellitus (DM) are yet to be fully understood. To address this, we conducted a comprehensive meta-analysis of six randomized trials on individuals with overweight or obesity, without DM, which showed that tirzepatide, when compared with placebo, resulted in a change in percentage body weight with a mean difference (MD) of -16.32% (95% CI: -18.35 to -14.29) and change in absolute body weight in kilograms (MD -13.95 kg; -18.83 to -9.07). There were significant reductions in body mass index and waist circumference when compared with placebo, with MDs of -5.89 kg/m² (-8.97 to -2.81) and -12.31 cm

SUBMITTER: Kommu S 

PROVIDER: S-EPMC12531717 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature