The Noncoding Mutational Landscape of Pancreatic Cancer Reveals Recurrent Somatic Mutations in Enhancer Regions.

ABSTRACT: While the coding genome of pancreatic cancer has been characterized in detail, features of the noncoding genome remain relatively unexplored. We used whole-genome sequencing to study the coding and noncoding genomes (promoters, enhancers, and noncoding-nonenhancer regions) in two unique patient cohorts. We find that treated cancers have a significantly higher mutational burden than untreated cancers in all four genomic regions. However, the relative proportion of mutations in each region is preserved despite treatment-induced genetic bottlenecks. Compared with other noncoding regions, enhancers have a lower number of mutations/Mb. Enhancers also have a distinct mutational signature with enrichment of SBS39. Enhancer sequences were segregated into conserved and nonconserved regions based on

SUBMITTER: Hayashi A 

PROVIDER: S-EPMC12531768 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature