On The Retrograde Transport of RNA-Loaded Lipid Nanoparticles Designed for Brain Delivery.

ABSTRACT: Lipid nanoparticles (LNP) have been extensively studied for their ability to encapsulate and protect RNA molecules from degradation. More recently, a few studies have begun to explore their applications as carriers for brain drug delivery via various administration routes. Nose-to-brain delivery represents a promising alternative to both invasive local injections and systemic administration, offering the possibility to bypass the blood-brain barrier and directly access the brain, achieve rapid absorption, reduce systemic exposure, and allow for ease of administration. In order to evaluate the viability of this alternative route, it is essential to acquire a better understanding of the intraneuronal mass transport of LNP, particularly in terms of how effectively and efficiently they deliver

SUBMITTER: Mamberti S 

PROVIDER: S-EPMC12531864 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature