Targeted Protein Degradation for Agricultural Applications: Rationale, Challenges, and Outlook.

ABSTRACT: Farmers urgently need novel technologies to ensure global food security for the rapidly expanding population, yet crop protection has seen little innovation in decades. Mounting regulatory pressures, pest resistance, and environmental concerns are driving demand for novel sustainable solutions. Beyond traditional small molecule active ingredients, very few alternative modalities (e.g., peptides, RNAi, biopesticides) have reached the market. Meanwhile, targeted protein degradation (TPD) has emerged as a breakthrough modality for human therapeutics, with numerous proteolysis-targeting chimeras (PROTACs) and molecular glues (MGs) advancing through clinical trials. Those compounds induce potent and selective degradation of protein targets via the ubiquitin-proteasome system (UPS). Recen

SUBMITTER: Fourches D 

PROVIDER: S-EPMC12531867 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature