Examination of metabolic syndrome in Down syndrome and association with dementia.

ABSTRACT:

Introduction

In the neurotypical population, metabolic syndrome (MetS) is associated with Alzheimer's disease (AD). However, this has not been well studied in adults with Down syndrome (DS).

Methods

The prevalence of MetS and its subcomponents was examined in adults with DS using the Alzheimer Biomarkers Consortium - Down Syndrome data (ABC-DS, N = 389). Logistic regression was used to examine the relationship between MetS and AD at baseline visits.

Results

Prevalence of MetS, diabetes, hypertension, and hyperlipidemia was low with DS, even though the prevalence of obesity was elevated. Obesity was positively associated with AD in adults with DS (odds ratio = 2.79, P = 0.021), but there was no association between MetS and AD in DS.

Discussion

The prevalence of

SUBMITTER: Dass D 

PROVIDER: S-EPMC12531894 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature