Genome-wide association study and polygenic risk scores of eosinophilia in Taiwan.

ABSTRACT:

Objectives

Eosinophilia, characterised by elevated eosinophil levels, is associated with various allergic and inflammatory conditions. This study aimed to elucidate the genetic determinants of eosinophil levels by examining polygenic risk scores (PRS) and identifying significant single nucleotide polymorphisms (SNPs).

Methods

We conducted a comprehensive genome-wide association study (GWAS) on eosinophil levels using a large cohort, comprising 221 851 controls (eosinophil levels ≤ 5%) and 11 200 cases (eosinophil levels > 5%) in Taiwan. The analysis included covariates such as age, sex and the first 10 principal components to account for population stratification. Polygenic risk scores were calculated, and their associations with eosinophil levels were evaluated.

Results<

SUBMITTER: Lu HF 

PROVIDER: S-EPMC12531897 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature