Carotid and regional arterial stiffness and dementia-related imaging biomarkers in the Multi-Ethnic Study of Atherosclerosis (MESA).

ABSTRACT:

Introduction

Arterial stiffness measured within various arterial beds may be differentially associated with neuroimaging biomarkers of dementia.

Methods

We related carotid and regional (cardio-ankle vascular index [CAVI] and heart-ankle pulse wave velocity [haPWV]) arterial stiffness measures to biomarkers (gray matter volume [GMV], white matter hyperintensity volume [WMHV], and fractional anisotropy [WMFA]) and amyloid positron emission tomography (PET) positivity (centiloid > 12.2), controlling for covariates.

Results

All arterial stiffness measures were associated with higher WMHV. Lower carotid distensibility (increased mechanical stress) was positively associated with WMFA, while Young's elastic modulus and haPWV (greater stiffness) were associated with lower WMF

SUBMITTER: Emrani S 

PROVIDER: S-EPMC12531903 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature