The Road Less Traveled: Exploring the Genomic Characteristics and Antimicrobial Resistance Potential of Acinetobacter baumannii From the Indigenous Orang Asli Community in Peninsular Malaysia.

ABSTRACT: Acinetobacter baumannii is widely recognized as a multidrug-resistant pathogen, although most public genome datasets are biased toward hospital-derived isolates. Little is known about A. baumannii isolates from healthy individuals in the community. This study analyzed genome sequences from nine A. baumannii isolates obtained from the upper respiratory tract of the indigenous Orang Asli in their rural community in Peninsular Malaysia. Genomic analysis revealed genetic diversity, including three new Pasteur sequence types (STs) and six novel Oxford STs. One isolate, A. baumannii 19064, belonged to Global Clone 8 (GC8), a lineage linked to clinical infections. Core genome phylogeny showed these community isolates interspersed with clinical isolates from a nearby hospital, indicating potential

SUBMITTER: Lean SS 

PROVIDER: S-EPMC12531904 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature