Impact of platelet transfusions on plasma proteomes in controlled endotoxemia and in hemato-oncological patients.

ABSTRACT:

Background

Inflammation is a hallmark of patients that receive platelet transfusions, including critically ill and hemato-oncological patients. Platelet transfusions have been suggested to exacerbate inflammatory conditions, resulting in transfusion-related complications. Here, we used plasma proteomics to study the impact of platelet transfusions under inflammatory conditions.

Methods

Plasma proteomics was performed in samples from two studies: (1) 252 samples from healthy volunteers from 36 cases divided into groups (n = 6) with and without controlled endotoxemia, each with different platelet products, and (2) 54 samples from 27 transfusion events in hemato-oncological patients (n = 14). Both studies had samples pre- and post-transfusions.

Results

Controlled endotox

SUBMITTER: Smit ER 

PROVIDER: S-EPMC12531923 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature