Proteomic profiling of bone tissue reveals distinct pathways in men and women with osteoporosis.

ABSTRACT:

Background

Osteoporosis is characterised by an imbalance in bone remodelling, yet the detailed molecular mechanisms underlying its pathogenesis remain unclear. This study aimed to identify key proteins and regulatory pathways associated with severe osteoporosis in women and men.

Methods

Bone specimens were collected during surgery from 13 women and 12 men with osteoporotic fractures, along with 8 female and 7 male controls with violent fractures. Differentially abundant proteins (DAPs) in bone tissues were identified via nontargeted liquid chromatography-tandem mass spectrometry proteomics. Functional enrichment and pathway analyses were performed; the diagnostic potential of core DAPs was evaluated through multivariate receiver operating characteristic (ROC) analysis, and c

SUBMITTER: Lin X 

PROVIDER: S-EPMC12531983 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature