Dysregulated vitamin D signaling in Hashimoto's thyroiditis: an integrated transcriptomic study in a Korean cohort.

ABSTRACT:

Background

Hashimoto's thyroiditis (HT) is the most common thyroid disease leading to hypothyroidism in developed countries. Recent studies have highlighted vitamin D as a potential risk factor or therapeutic agent for HT owing to its role in modulating immune responses, although concrete evidence has not been presented. This retrospective observational study was conducted to investigate serum vitamin D levels and dysregulation of vitamin D signaling pathways in patients with HT.

Methods

Patients who underwent thyroid surgery for various thyroid neoplasm with or without HT were recruited. We analyzed serum thyroid biomarkers, including serum vitamin D, anti-thyroglobulin (TG) antibody, and anti-thyroid peroxidase (TPO) antibody for patients with HT. Using RNA-seq, the gene e

SUBMITTER: Lim DW 

PROVIDER: S-EPMC12532006 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature