Lactose-conjugated 2-iminothiazolidin-4-ones: synthesis, inhibitory activity and molecular simulations as potential inhibitors against enzymes responsible for type 2 diabetes.

ABSTRACT: A series of new substituted lactose-conjugated 2-iminothiazolidin-4-ones 7a-h were synthesized and scanned for their inhibitory activity against enzymes responsible for type 2 diabetes, including α-amylase, α-glucosidase, DPP-4, and PTP1B. Three lactose-conjugated 2-iminothiazolidin-4-ones 7c, 7e, and 7f exhibited the highest inhibitory activity against the selected enzymes. Compounds 7c and 7e were the strongest inhibitors for DPP-4 and α-amylase, respectively, whereas 7f exhibited strong inhibition against α-glucosidase and PTP1B. These compounds had also high anti-glycation and antioxidant activities and were not cytotoxic to the WI-38 cell line. A molecular docking study was applied to the three most potent inhibitors 7c, 7e, and 7f in inhibition against enzymes 1OSE, 3TOP, 3W2T, and 1

SUBMITTER: Thi Kim Van H 

PROVIDER: S-EPMC12532039 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature