Iron-catalyzed stereoselective glycosylation for 1,2-cis-aminoglycoside assembly.

ABSTRACT: Complex carbohydrates are essential to life processes, but it is challenging to isolate these molecules from natural sources in high homogeneity. Therefore, complex-glycan synthesis becomes critical to improving our understanding of their important functions. Due to their complexity, synthesis is still difficult for nonexperts. One of the key challenges is to search for general solutions for highly 1,2-cis-selective glycosylation, which will directly assemble 1,2-cis-2-aminoglycosides that are incorporated in numerous biologically important complex glycans and glycoconjugates. Here we describe an iron-catalyzed, chemical glycosylation method for rapid assembly of 1,2-cis-aminoglycosidic linkages. The iron catalyst is commercially available, and the bench-stable supporting ligand and aminat

SUBMITTER: Jiang Z 

PROVIDER: S-EPMC12532069 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature