Iron-Catalyzed Highly Stereospecific Glycosylation with Glycal Epoxides.

ABSTRACT: Complex carbohydrates are essential to understanding life processes, but their synthesis is still challenging. In principle, complex glycans could be rapidly assembled via reiterative and stereospecific glycosylation with glycal epoxides. However, the existing stereospecific glycosylation methods with glycal epoxides are ineffective for the vast majority of secondary sugar acceptors, because they often induce irreversible glycal epoxide decomposition and concurrent S_N1-type glycosylation, affording an inseparable mixture of diastereomeric glycosylation products in low yields. We report herein a new catalytic, highly stereospecific glycosylation method for glycal epoxides using readily available iron catalysts. This method is effective for a wide variety of glycal epoxides and gl

SUBMITTER: Zhang XW 

PROVIDER: S-EPMC12532074 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature