Nanoparticle to Nanoparticle Bioorthogonal Detection of Atherosclerosis.

ABSTRACT: In vivo identification and characterization of atherosclerosis is a promising approach for the development of novel therapies and personalized treatments. Among the methods for this in vivo identification, the use of pretargeted imaging shows very large probe uptakes and excellent selectivity. However, this approach relies on the use of antibodies which may limit their usability. In this study, we introduce a pretargeting imaging approach for atherosclerosis detection using PET that only employs nanomaterials. Here we develop the concept of nanoparticle-to-nanoparticle pretargeted imaging for atherosclerosis. Sphingomyelin solid lipid nanoparticles (sphNP) functionalized with trans-cyclooctene (TCO) were used as targeting agents and accumulated in atherosclerotic plaques. Thi

SUBMITTER: Munoz-Hernando M 

PROVIDER: S-EPMC12532092 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature