Modulating Electrostatic Interactions to Control the Analyte Transport in Nanochannels.

ABSTRACT: Ion-receptor binding is a key mechanism underlying various biological responses, which greatly inspires biomimetic approaches in technologies ranging from nanomedicine to energy storage and active membrane separation. Interaction between analytes and nanopores has been reported to either favor the transport (electrochemical studies performed in the millimolar concentration regime) or to slow down the diffusion in nanochannels (single-molecule investigations in the nanomolar range). Here, we propose a simple and inexpensive fluorescence setup for monitoring submicromolar diffusion, which effectively bridges these two concentration regimes, and show that at micromolar concentration, electrostatic interactions between the analyte (Ru(bpy)₃²⁺) and nanochannel walls slow d

SUBMITTER: Varol HS 

PROVIDER: S-EPMC12532097 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature