Circulating immune landscape and immune signatures in spontaneous HIV controllers.

ABSTRACT: A subset of people with HIV, termed HIV controllers (HIC), maintain low viral loads without antiretroviral therapy. To identify the immune cell architecture of HIV control, we profiled peripheral blood from 54 HIC (including 21 elite controllers, EC) and 1,044 non-controllers (non-HIC) in the 2000HIV study (NCT03994835) using high-dimensional cytometry and confounder-adjusted regression analysis. Both HIC and EC exhibited distinct innate immune profiles compared to non-HIC, marked by reduced frequencies of CCR5⁺ NKT and TCRγδ1⁺ cells. EC further showed increased neutrophils and TCRγδ2⁺ cells, and reduced eosinophils. Unsupervised clustering revealed elevated CD11c and CD1c expression on TCRγδ2⁺ cells in EC, correlating with IFNγ production, sugge

SUBMITTER: Navas A 

PROVIDER: S-EPMC12532132 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature