Nonmimetic Gels Direct Novel Crystallization Behavior of Lenalidomide.

ABSTRACT: Crystallization within supramolecular gels can yield distinct solid-state outcomes compared with conventional solution-phase methods, including the formation of novel crystal forms or selectively crystallizing one crystal form from a concomitant mixture. In several cases, tailoring the molecular structure of a gelator to mimic a pharmaceutical substrate has facilitated crystallization control, where nonmimetic gelators had no influence on the crystallization outcome compared to the solution phase. In this study, we investigate the crystallization behavior of lenalidomide within both mimetic and nonmimetic gels. Crystallization in a cyclopentanone gel using a nonmimetic gelator led to the discovery of a novel cyclopentanone hemisolvate, inaccessible via solution-phase crystallization. Addit

SUBMITTER: Screen MA 

PROVIDER: S-EPMC12532200 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature