Optical imaging unveils morphological heterogeneity at the hepatic lobule level during metabolic dysfunction-associated fatty liver disease progression [Invited].

ABSTRACT: Hepatic lobules constitute the fundamental structural and functional units of the liver, which are essential for maintaining microcirculatory homeostasis, barrier integrity, and metabolic clearance. Optical imaging techniques, including photoacoustic microscopy (PAM) and near-infrared-II (NIR-II) fluorescence imaging, have been extensively employed to investigate liver structure and function. However, few studies have specifically addressed the structural and functional heterogeneity at the lobular level. In this study, we developed a dual-modal approach combining high-resolution PAM and dynamical NIR-II fluorescence imaging to assess hepatic lobular vascular structure, permeability, and metabolic function in the models of metabolic dysfunction-associated fatty liver disease (MAFLD). PAM i

SUBMITTER: Zhou Q 

PROVIDER: S-EPMC12532305 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature