Evaluation of radio frequency ablation in human left atrial tissues for atrial fibrillation using optical coherence tomography.

ABSTRACT: Despite its widespread adoption, the success of radiofrequency (RF) ablation is often limited by challenges in achieving durable, transmural lesions while avoiding complications such as incomplete ablation or over-ablation. Optical coherence tomography (OCT) offers high-resolution visualization of cardiac tissue, enabling real-time assessment of lesion depth. Therefore, we investigated the impact of RF ablation on donated human left atrial tissue using an OCT imaging system to assess lesion formation in a controlled laboratory setting. RF ablation lesions were created at durations of 20, 40, 60, 80, and 100 seconds (s), and their effects were quantified by calculating the attenuation coefficient from OCT images. To identify tissue regions in the image, a U-Net model was employed for segmen

SUBMITTER: Selvaraj Mercyshalinie ER 

PROVIDER: S-EPMC12532330 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature