Comparative metabolomic profiling reveals distinct metabolic signatures in amniotic fluid and umbilical cord blood between advanced and young maternal age pregnancies.

ABSTRACT:

Background

Given the heightened risk of complications during pregnancy in women of advanced maternal age (AMA), it is crucial to understand the metabolites in amniotic fluid and umbilical cord blood in this demographic.  METHODS: We analyzed the metabolites in amniotic fluid from 60 women, divided into two groups: the AMA group (aged 35 or above, n = 29), and the control group (aged below 35, n = 31). We then conducted a follow-up analysis on the metabolites of umbilical cord blood from a sample of 19 women (9 from the AMA group, and 10 from the control group).

Results

In total, we identified 96 differential metabolites in the amniotic fluid and 146 in the cord blood between the two groups. The significant changes in the metabolites of the amniotic fluid mainly involved sphi

SUBMITTER: Li D 

PROVIDER: S-EPMC12532403 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature