Bacterial sexually transmitted infections and related antibiotic use among individuals eligible for doxycycline post-exposure prophylaxis in the United States.

ABSTRACT: While doxycycline postexposure prophylaxis (doxyPEP) can prevent bacterial sexually transmitted infections (STIs), concern surrounds the volume of antibiotic use needed to realize this benefit. We estimated incidence rates of gonorrhea, chlamydia, and syphilis diagnoses and related antibiotic prescribing among US males and transgender individuals using Merative MarketScan® Research Databases during 2017-2019. Follow-up encompassed 38,543 person-years among recipients of HIV pre-exposure prophylaxis (PrEP), 29,228 person-years among people living with HIV (PLWH), and 19,918 person-years among people with prior-year STI diagnoses. Incidence rates of STI diagnoses among PLWH and PrEP recipients with ≥1 prior-year STI diagnosis totaled 33.3-35.5 per 100 person-years. Direct effects of doxyPEP

SUBMITTER: Parker AM 

PROVIDER: S-EPMC12532492 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature