Can ADC changes help mRECIST or LI-RADS treatment response algorithm better diagnose pathological response of HCC after preoperative radiotherapy? Secondary analysis of a prospective phase 2 trial.

ABSTRACT:

Objectives

To explore the role of apparent diffusion coefficient (ADC) changes in predicting pathological response to preoperative radiotherapy (RT) in hepatocellular carcinoma (HCC) compared to existing evaluation criteria, using histopathology as the reference standard.

Materials and methods

Building on the prospective clinical trial, we included 35 patients with 38 HCCs who underwent preoperative RT followed by hepatectomy between December 2014 and January 2019. Pre- and post-RT ADC parameters (ADC_roi and ADC_slice measured from representative areas and histogram parameters derived from whole-tumor volume) were compared, and the percentage change of parameters (Δ-parameters%) was calculated to correlate with major pathological response (MPR). The modi

SUBMITTER: Cong R 

PROVIDER: S-EPMC12532537 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature