Predictive markers of obesity and glucose metabolism dysfunction in adult common marmosets (Callithrix jacchus).

ABSTRACT:

Objective

Characterize the effects of obesity on common marmoset glucose metabolism and develop predictive markers of glucose metabolism dysfunction.

Methods

Body size, weight, lean mass, fat mass, %fat, resting energy expenditure (REE), and glycosylated hemoglobin (HbA1c) were measured on 51 adult marmosets. Physical activity was assessed using actimeter collars (n = 50). A body mass-per-length parameter (BML) was constructed. Animals were classified as without obesity or with obesity (%fat >10%) and by the age they obtained maximum weight (Maxwt). Correlation, MANOVA, and binary logistic regression were used to examine relationships between parameters; path analysis to explore directional relationships.

Results

Body fat and BML were correlated (r = 0.565, p < 0.001)

SUBMITTER: Arroyo JP 

PROVIDER: S-EPMC12532565 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature