Alterations in miR-151a-3p of plasma-derived exosomes and associated multimodal neuroimaging patterns in major depressive disorder.

ABSTRACT: Magnetic resonance imaging (MRI) has been recognized as a valuable tool for achieving 'reification of clinical diagnosis' of major depressive disorder (MDD). However, the reliability and validity of MRI results are often compromised by genetic, environmental, and clinical heterogeneity within test samples. Here, we combined MRI with other clinical findings using multimodal MRI fusion algorithm to construct a data-driven, bottom-up diagnostic approach. The covariation patterns between the multimodal MRI features and differential expression of exosomal microRNA (miRNA) were identified on a subset of 70 MDD patients and 71 healthy controls (HCs) (served as a training set) as classification features, whereas data from the other 45 MDD patients and 43 HCs served as a test set. Furthermore, long

SUBMITTER: Liang W 

PROVIDER: S-EPMC12532566 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature