Patritumab deruxtecan in HR⁺HER2^- advanced breast cancer: a phase 2 trial.

ABSTRACT: Antibody-drug conjugates have shown impressive clinical outcomes, particularly in metastatic breast cancer, but biomarkers to predict response and resistance remain unidentified. Here we report the results of ICARUS-BREAST01, a phase 2 study evaluating efficacy, safety and biomarkers of response and resistance to patritumab deruxtecan (HER3-DXd), in patients with HR⁺HER2^- metastatic breast cancer, who previously progressed on CDK4/6 inhibitors and one line of chemotherapy. From May 2021 to June 2023, 99 patients were enrolled to receive HER3-DXd 5.6 mg kg^-1 intravenously every 3 weeks. The study met its primary endpoint, showing an overall response rate of 53.5% (90% confidence interval [44.8-62.1%]). The most frequent adverse events were fatigue (83%), nau

SUBMITTER: Pistilli B 

PROVIDER: S-EPMC12532567 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature