Evidence of bidirectional relationship between type 2 diabetes and depression; a Mendelian randomization study.

ABSTRACT: Major depressive disorder (MDD) and type 2 diabetes (T2D) represent two global health challenges with a high degree of co-occurrence. Here, we aim to investigate the causal relationship between MDD and T2D in diverse ancestries using Mendelian randomization (MR) in GWAS summary statistic and individual level (UK Biobank (UKB)) data. We assessed the bi-directional causal relationship between: (a) MDD and T2D and (b) MDD and glycaemic biomarkers (e.g. TG:HDL-C ratio, a measure of insulin resistance, fasting glucose) in non-diabetic individuals. In UKB we also tested the role of T2D on treatment resistant depression (TRD). We used multivariable MR (MVMR) to assess the role of body mass index (BMI) in the MDD to T2D relationship. Our results demonstrated that a doubling in MDD genetic liabilit

SUBMITTER: Bala R 

PROVIDER: S-EPMC12532585 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature