Interpeduncular GABAergic neuron function controls threat processing and innate defensive adaptive learning.

ABSTRACT: The selection of appropriate defensive behaviors in the face of potential threat is fundamental to survival. Equally important is learning to adjust and optimize defensive behaviors when there is no real danger. Despite extensive research on innate threat processing, little is known about the mechanisms by which individuals adapt their defensive behaviors in response to repeated threats that lack real danger. Insight into this process is critical as its dysregulation may contribute to neuropsychiatric conditions, such as anxiety disorders. Here, we used the visual looming stimulus (VLS) paradigm in mice to investigate innate threat processing and adaptive defensive learning. Repeated exposure to VLS over consecutive sessions reduced immediate freezing responses and time spent inside a shel

SUBMITTER: Williams EW 

PROVIDER: S-EPMC12532598 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature