Proteomic analysis of dental pulp from deciduous teeth in comparison to permanent teeth: an in-vitro study.

ABSTRACT:

Purpose

The aims of this study were to identify proteomic profiles of dental pulp from deciduous teeth and compare the profiles of the two dentitions.

Methods

Teeth that were caries-free and had normal pulp conditions were collected from twelve healthy individuals. The obtained teeth consisted of deciduous teeth (n = 6) and permanent teeth (n = 6). Proteins were extracted from pulp tissue and then analysed using liquid chromatography-tandem mass spectrometry. MaxQuant was used to identify and quantify proteins from raw mass spectrometry data of the collected deciduous and previously analysed permanent dental pulp. Differentially expressed proteins (DEPs) between the dental pulp of the two dentitions were identified by a statistical analysis conducted using Metaboanalyst with

SUBMITTER: Horsophonphong S 

PROVIDER: S-EPMC12532624 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature