Spatial metabolomics reveals the effects of Acanthopanax senticosus on region-specific alterations in neurotransmitters and metabolites levels in the brains of α-syn transgenic Parkinson's disease model mice.

ABSTRACT:

Background

Acanthopanax senticosus (Rupr. et. Maxim.) Harms (ASH), a widely used traditional Chinese herbal medicine, possesses various therapeutic effects, such as the ability to tonify the spleen and kidney, strengthen muscles and bones, and promote consciousness and nerve relaxation. Previous research has indicated its good efficacy in treating Parkinson's disease (PD). We aimed to investigate the effects of ASH on changes in neurotransmitter and metabolite levels within the brain tissue of α-synuclein (α-syn) transgenic mice with PD. Additionally, we sought to explore the potential mechanisms by which ASH treats PD and the targets of action of ASH. α-Syn transgenic mice were chosen as a suitable model of PD. Hematoxylin‒eosin (HE) staining was used to detect changes in neurons

SUBMITTER: Zheng Q 

PROVIDER: S-EPMC12532642 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature