Identifying brain functional subtypes and corresponding task performance profiles in autism spectrum disorder.

ABSTRACT: Refining the classification of autism spectrum disorder (ASD) subtypes is essential for advancing personalized interventions strategies, given the substantial heterogeneity in phenotypic clinical symptoms among individuals with ASD. Thus, the current study integrated normative modeling, resting-state fMRI data, clinical assessment, and eye-gaze patterns to investigate potential ASD subtypes. By incorporating both static and instant dynamic (strength and variability) functional connectivity as predictive variables within the normative models, we aimed to delineate multi-level functional developmental trajectories. Our comprehensive analysis of 1046 participants (479 with ASD, 567 typical development) identified two distinct neural ASD subtypes with unique functional brain network profiles d

SUBMITTER: Liu Q 

PROVIDER: S-EPMC12532700 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature