Upregulation of adenosine A_2A receptor in astrocytes is sufficient to trigger hippocampal multicellular dysfunctions and memory deficits.

ABSTRACT: Adenosine is an ubiquitous neuromodulator that ensures cerebral homeostasis. It exerts numerous functions through the activation of G-protein-coupled adenosine receptors (ARs), in particular A₁ (A₁R) and A_2A (A_2AR) receptors. Interestingly, A_2AR levels are upregulated in cortical and hippocampal regions in several pathological conditions such as Alzheimer's disease, tauopathies or epilepsia. Such abnormal upregulations have been particularly reported in astrocytes, glial cells that play a key role in regulating synaptic plasticity. However, the overall impact and the underlying mechanisms associated with increased A_2AR in astrocytes remain poorly understood. In the present study, we induced the upregulation of A_2A

SUBMITTER: Launay A 

PROVIDER: S-EPMC12532706 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature