Opposing roles of microglial and macrophagic C3ar1 signaling in stress-induced synaptic and behavioral changes.

ABSTRACT: The social deficits following chronic stress conditions are linked to synaptic dysfunction in the brain. Complement system plays a critical role in synapse regulation. Although complement has been implicated in chronic stress-induced behavior deficits the cellular substrates and mechanisms underlying complement-mediated behavior changes under chronic stress conditions are not known. In the present study, we investigated the role of complement component 3a receptor (C3ar1) in microglia and monocytes/macrophages (Mo/MΦ) in chronic unpredictable stress (CUS)-induced synapse loss and behavior deficits in mice. We found that deletion of microglial C3ar1 attenuated stress-induced social behavior deficits and changes in neuroinflammatory as well as synaptic markers in the prefrontal cortex (PFC).

SUBMITTER: Tripathi A 

PROVIDER: S-EPMC12532727 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature